taking strayhaving surgery

A dog with an unbelievable sense of smell has been able to sniff out thyroid cancer in people not yet diagnosed with the disease.US researchers said that on a test of 34 patients, Frankie the German Shepherd showed 88 per cent accuracy in finding tumours.Frankie was trained to lie down when he could smell thyroid cancer in a sample of urine and turn away if it was clean.
A dog with an unbelievable sense of smell has been able to sniff out thyroid cancer in people not yet been diagnosed with the disease. The US researchers said that on a test of 34 patients, Frankie the German Shepherd showed 88 per cent accuracy in finding tumoursResearchers at the University of Arkansas said Frankie only made two false positives and two incorrect all-clear diagnoses.What we have done, no one has attempted to do, said lead author Arny Ferrando, who noted past studies showing trained dogs can reliably tell the difference between cancerous and non-cancerous tissues.
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We have taken the next step by asking the dog to tell us whether or not cancer exists before the medical diagnostic system does. We wanted to see, can the doctor utilise the dog to help diagnose cancer?Thyroid tumours, which occur in a gland in the neck, are relatively rare and usually diagnosed by taking a blood sample and testing its hormone levels.
Frankie was trained to lie down when he could smell thyroid cancer in a sample of urine and turn away if it was clean. Thyroid tumours (artists illustration right), which occur in a gland in the neck, are relatively rare and usually diagnosed by taking a blood sample and testing its hormone levelsDetecting and diagnosing thyroid cancer can be difficult, because its often looking for a very small number of occurrences in a very large background of benign nodules, said Dr Donald Bodenner at the University of Arkansas.It is also difficult to say with certainty that a patient is cancer-free after surgery.Dogs, however, can sense it as their ability to smell is 10 times better than that of humans.The researchers now want to see if Frankie, and other dogs, could be used as a diagnostic test for different types of cancer.  Cancer Research UK told the BBC that using dogs would be impractical. However, it added that discovering the chemicals the dogs can smell could lead to better tests.
Researchers at the University of Arkansas said Frankie only made two false positives and two incorrect all-clear diagnoses. He is pictured here. Pictured is Dr Arny Ferrando, who found Frankie as a strayHaving a technique with which to do these things with a higher degree of certainty would be a tremendous advance in thyroid cancer, said Dr Bodenner.The implications could be tremendous, the researchers said, both in terms of cost savings in diagnoses and especially the prevention of unnecessary surgeries.Additionally, the method could be transported to under-served areas where traditional detection methods of biopsy and ultrasound are unavailable.The researchers believe the training could also potentially be used in diagnosis of other cancers such as ovarian, breast, kidney, bladder and prostate. THE RESCUE DOG WHO SNIFFED OUT HIS OWNERS BREAST CANCER
Josie Conlan, 46, had no idea she had a lump in her breast until her two-year-old border collie Ted began to repeatedly cry, paw and nuzzle at her chestEarlier this year, it was revealed a woman has had an aggressive cancerous tumour removed after the dog she rescued from a life of misery sniffed out an aggressive tumour in the nick of time.Josie Conlan, 46, had no idea she had a cancerous lump in her breast until her two-year-old border collie Ted began to repeatedly cry, paw and nuzzle at her chest – and she now credits him with saving her life.The mother-of-four from Stockton-on-Tees wondered what was wrong, and when she put her hand to her chest she realised she had a lump.She visited her GP and was diagnosed with cancer but has now had the tumour, which she was told was advanced at grade three, removed. In the two weeks before she was operated on the lump had grown by an incredible five millimetres and Josie believes that if it wasnt for Ted she could have been dead by summer. Stay-at-home-mum Josie now wants to let other people know that they should take notice of dogs if they start to draw attention to a certain area of their owners body.  Thyroid cancer is our template, said Dr Ferrando. Its one of the fastest growing cancers in terms of occurrences in the world.Its not one of the highest mortality cancers, but one of the fastest growing in terms of newly diagnosed cases.So far the team has used what are termed general source dogs, or strays that have been trained in scent detection methods.Their plan is to now work with researchers at Auburn Universitys Canine Performance Sciences program in the College of Veterinary Medicine to teach and imprint specific purpose dogs, or those specifically bred for detection.If we do 300 samples with a diagnostic accuracy of 90 percent, thats pretty hard to ignore, especially if it comes from Auburn, which has been doing canine training for 25 years, added Dr Ferrando.
What we have done, no one has attempted to do, said lead author Arny Ferrando (pictured), who noted past studies showing trained dogs can tell the difference between various cancerous and non-cancerous tissuesBBC News – Frankie the dog sniffs out thyroid cancer

Cuba as the jr

For years it was Americas tropical playground and now, thanks to an easing to relations between the US and Cuba, tourists could once again explore the nation thats been cut off from its neighbor for 55 years.The former mafia-run restaurants, nightclubs, and glamorous hotels of pre-revolution Havana are still standing and historian Peter Moruzzi has penned a book guiding visitors through the highlights of Cuba before 1959, when Castro swept in to power.Describing the capital as the crown jewel of the American Mobs underworld empire, the historian explores the amazing sites that have survived the intervening 55 years – towering reminders of a time when mobsters like Meyer Lansky and Santo Trafficante Jr. ran the roulette wheels, craps games, and card tables across the city. 
A two-story abstract metal sculpture by Cundo Bermudez continues to center the circular staircase of the Havana Rivieras lobby
The Hotel Nacional de Cuba as it looks today; it was the site of the infamous 1946 mob summit presided over by capo Lucky Luciano. Wilber Clarks Casino International opened in the Hotel Nacional in 1955.Speaking to MailOnline Travel about his book Havana Before Castro: When Cuba Was a Tropical Playground, Moruzzi explained: There has never been a better time to explore Havanas Mob-related past.Almost all of the fabulous mid-century hotels and restaurants built by the Mob still exist in their original 1950s splendour.
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By 1958, the Mob had transformed Havana into the Las Vegas of the Caribbean. At Santo Trafficantes ultra-modern Hotel Capri, Hollywood actor and casino host George Raft stood atop a craps table and successfully kept the revolutionaries from destroying the casino in exchange for a free buffet. Down the hill at the bottom of 21st Street stands the venerable Hotel Nacional de Cuba overlooking the sea. Built in 1930, this doyenne of Havana hostelries blends Spanish, Moorish, classical, and Art Deco elements in its imposing design. 
The dazzling Hotel Capri in 1957, and right, author Peter Moruzzi smoking a Montecristo #2 in the heart of Havana
Meyer Lanskys new Riviera casino as rendered in 1957; an eclectic mix of the rich and famous enjoyed Havanas gambling cultureMoruzzi explains: The Nacional hosted Lucky Lucianos infamous 1946 mafia summit attended by the biggest gangsters of the era, including Lansky, Frank Costello, Albert Anastasia, Vito Genovese, Joe Adonis, Joe and Rocco Fischetti, Moe Dalitz, and Santo Trafficante Jr.Topping the summits Christmas week celebrations was a performance by the young Italian-American crooner Frank Sinatra, of whose success the Mob leaders were very proud. In 1955, Lansky inaugurated the hotels glittering new Casino International with Wilbur Clark of Las Vegas Desert Inn serving as front man. Today, guests can enjoy a frosty mojito on the hotels veranda after wandering the spacious grounds. Another monument to the Mob days of Havana is Meyer Lanskys spectacular 440-room seaside Havana Riviera hotel of 1957. 
Havana casino kingpin Meyer Lansky pictured in 1958, and right, Hollywood actor George Raft who played the role of a gangster in several films was hired to be the genial host at Santo Trafficantes Casino de Capri
American actor George Raft (centre) laughs as he sits at a gambling table at the Casino de Capri, Havana
Wilbur Clark was the mobs front man for Las Vegas Desert Inn and Havanas Hotel Nacional de Cuba, and right, The Hotel Capri was built by Santo Trafficante Jr. of Tampa, Florida in 1958Its as over-the-top as the Fontainebleau in Miami Beach, yet as sleek and sophisticated as the Rat Packs Sands Hotel was in Las Vegas, says Moruzzi. The Havana Riviera is now the best-preserved example of a swank 1950s resort hotel in the world. Standing in the lobby one is transported to the height of pre-Castro glamour as it once existed in Havana.Today the Havana Riviera remains virtually unmolested in its original 1957 splendor. Indeed, according to Moruzzi, due to benign neglect, the Riviera has become the best-preserved example of mid-century Las Vegas/Miami Modern resort architecture in the world. 
Meyer Lansky and Lucky Luciano were big game players in the Mob scene prior to Castro coming into power in Cuba
How the brochure for the Nacional appeared in 1958, promising much fun in the sun
Trafficante also had ownership stakes in the casinos at the Hotel Comodoro and Sans Souci nightclub. Although the Sans Souci is gone, the Comodoro can be found at the beach in Miramar.Entering the hotels lobby magically transports you – without needing to avert your eyes or pretending to ignore historically inappropriate intrusions – back to the height of pre-Castro glamour as it once existed in Havana. Go there before some self-important design consultant takes charge and strips the hotel of its irreplaceable character, adds Moruzzi. The last and biggest of the pre-Castro hotel-casinos was the Habana Hilton, visible from almost any vantage point in the city – it was renamed the Habana Libre when Castro entered the city to take control of Cuba.The hotels 30 stories contain 630 rooms, two enormous ballrooms, a huge swimming pool, rooftop lounge and, originally, a glamorous casino.According to various sources, competition among the mob for obtaining the Hiltons casino license was so extreme that it was one of the more plausible motives for the October 1957 murder of capo Albert Anastasia while he was getting a shave at a New York hotel. 
The Hotel Capri was built by Santo Trafficante Jr. of Tampa, Florida in 1958, and right, the swanky Hotel Deauville, still located along the Malecon at Calle Galiano, had its own mob run casino
Meyer Lanskys Havana Riviera in recent years. Its location on the Malecon at Paseo is stunningMoruzzi added: (You can) explore the vast hotel with its beautiful sculptures and artwork including Amelia Pelaezs enormous black, blue and white mosaic tile mural inspired by the fruits and flowers of Cuba. Pelaezs mural transformed the building from a mere hotel to an artistic tour de force. The Habana Libre also houses a former Trader Vics Polynesian bar/restaurant. Renamed the Polinesio, it has slept in a Cinderella slumber, remaining as one of the worlds best-preserved examples of the style. While the food and drinks may have suffered, the faux Polynesian décor is astounding.
Three women perched on the bar at the Cabaret Kursal nightclub in Havana, Cuba, circa 1950
Time travel to 1958 is still possible at the Riviera, the best-preserved mid-century Vegas/Miami Modern resort hotel in the world; even its interior furnishings are originalMob-controlled casinos materialised in other Havana hotels and several upscale restaurants during this period, including the hotels Deauville and St. Johns, and the elegant Monseigneur restaurant (with Meyer Lansky as part owner) are located across the street from the Hotel Nacional. All can be explored by foot.Many of us are deeply worried that the midcentury architectural beauty of Havana might be erased if new investment leads to wanton renovation and demolition, explained Moruzzi. Perhaps this wont be the case if it becomes clear that preserving the citys 1950s architectural heritage will ensure the growth of a robust tourist industry for the benefit of all Cubans.Moruzzis richly illustrated book provides tour maps, vintage photos and histories of the Mob-run restaurants, nightclubs, and hotels of pre-revolution Havana. The authors website can be viewed at http://www.havanabeforecastro.com/ while the book can be purchased here.
Read more:
Havana Before Castro: When Cuba was a Tropical Playground: Peter Moruzzi: 9781423603672: Amazon.com: Books
Havana Before Castro: When Cuba Was a Tropical Playground by Peter Moruzzi

makin ıtalian

Its not all in the stars for guests when it comes to comparing the best hotels around Europe. While five stars seems like a fairly straight-forward measurement, hotel and resort ratings arent all created equal as there is no uniform ratings system to keep it simple for tourists.According to research by Previous
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In Great Britain, star ratings focus heavily on customer service, with a hotel not qualifying as a five-star without a greeting at the entrance and multilingual staff, along with a high quality food and wine menu and many other factors. While British standards are agreed by the AA (Automobile Association), VisitBritain, VisitScotland and VisitWales, Frances exacting standards on what makes a five-star hotel – based on rooms, lobbies, services and amenities  – were decided by their tourism authority and are enforced by the French Government. 
A long list of criteria for a five-star hotel in France, such as the Hotel du Louvre in Paris, includes staff speaking English and one other foreign language, valet parking, multiple pools and kids clubs
Standards for Spanish hotels, such as the Hotel Gran Melia Volcan lanzarote, are regulated regionally
Along with opulent interiors, Spains Hotel Alfonso XIII must have a 24-hour concierge service to be five-star FIVE OF THE BEST – FIVE THINGS THAT MAKE HOTELS FIVE-STAR QUALITY?   IN SPAIN Must offer the highest luxurySpecially adapted rooms for wheelchair users and will often provide extra facilities24-hour reception and 24-hour conciergeAward-winning on-site dining facilities Rooms cleaned daily, including fresh towels and bed linen, and a trouser press IN FRANCE Immaculate settingsStaff speak English and one other language Multiple pools, fitness centre, health and spa centres and kids clubs 24-hour room service Satellite television with a good range of channels IN GREAT BRITAINGuests are greeted at the hotel entranceHigh quality menu and wine listLicensed bar or lounge Service with attention to detail and qualityFormal reception and porters desks with uniformed staff offering proactive serviceExtensive range of facilities, including leisure, retail and conference services. IN ITALY  Offer at least three foreign language capabilitiesSingle rooms at least nine square meters and double at least 16 square metersAn elevatorBed sheet and towels changed dailyDaily cleaning and the room to be re-set in the afternoon. Free transfer service for clients and baggage  IN GREAT BRITAINGuests are greeted at the hotel entranceHigh quality menu and wine listLicensed bar or lounge Service with attention to detail and qualityFormal reception and porters desks with uniformed staff offering proactive serviceExtensive range of facilities, including leisure, retail and conference services. Spains five-star hotels are crowned regionally rather than nationally, meaning discrepancies are possible, but to be top of the line a hotel must have 24-hour reception and concierge, award-winning onsite dining facilities and the rooms must be cleaned daily. For the Italians, cleanliness is next to godliness for five-star hotels in their uniform star-rating system established in 2009 – a one-star hotel need only change bed sheets once a week but five-star, youll be pleased to know, have to change them daily. Most hotels in Turkey are inspected by the Ministry of Culture and Tourism while a similar system in compulsory in Portugal and regulated Ministry of Economy and Innovation.  
Italys hotel ratings system, established in 2009, is judged heavily on its standards of cleanliness
Along with its 18th-century design by Alfonso Torregiani, sheets are changed daily in Italian five-star hotels WHAT MATTERS MOST TO GUESTS Free Wi-Fi 65%English-speaking staff 53%Swimming pool 48%Guest parking 41$-hour reception 40%A safe in the room 39%Laundry and ironing services 11%Concierge services 9%Childrens club 7%A minibar in the room 7%A computer in the room 7%Step-free access 6%Fresh flowers/ present (e.g. chocolates) in the room on arrival 4%Sewing kit/ shoe polish kit in the room 4%Source: Hotels4u.com  As a member of HOTREC (Hotels, Restaurants & Cafés in Europe), Greek accommodation has complied with their classification system since 2013 with star ratings covering a combination of 270 compulsory and optional measurements.With such differences, Hotels4u.coms commercial manager Tim Bekir recommends tourists use a combination of peer and official review systems when making travel choices. When booking a hotel, its important to be as well informed as possible and confident with your choice, says Hotels4u.coms Commercial Manager Tim Bekir.Understandably, customers may sometimes find star ratings confusing. The Italian government, for example, have implemented a system that rates cleanliness as one of the most important aspects with the highest rated hotels being cleaned twice a day. France, on the other hand, focuses on more luxury and conveniences, such as room size, the location of the hotel and its amenities.Despite the variances, star ratings do give a good indication of the standard of the hotel. Thats why wed encourage using both peer-to-peer reviews and star ratings for the best hotel choice.